Archive for November 14th, 2007
4 items.
Yes, I know, I’m a horrible horrible contributor. But not without good reason. If not for me, none of these fools would’ve been able to make their post. Part of being a good leader is making sure things are working in the background. I would also like to take this time to thank Helen for figuring out the read more button. God it would’ve been awful to see more billion line Chad posts without it. No disrespect to Chad of course.
But I’ve also been working on getting everyone’s images ready and setting up a format for everyone’s posts, correcting a certain few people’s broken posts, and just general upkeep associated with starting a new blog. I assure you I have not been playing Super Mario Galaxy with the free time I don’t have. Surely I have not already completed that excellent game and am already on my way to one hundred and twenty stars.
Ok, I’m done with the excessive linking… for now. I would like to take this time to touch on a subject that I hate to bring up, but I must.
>edit<
I’m an idiot and the content that was here has been removed due to some violation that I stupidly was not aware of. Thanks Helen. Thanks for preventing me from getting banned.
Well, I have some work I need to get done. I am most assuredly not loading up Mario Galaxy to finish the last of the stars.
2 Comments
There is an epidemic starting around the world. Its been contained in the past, but it is breaking free and, quite frankly, it is starting to scare the bajeebus out of me. Be forewarned, because what I am about to tell you may shock and scare you. It may make you rethink having children. If you do have children, it may make you want to push them back into the womb. Here it goes…
More and more people are calling each other by names such as “Broseph” and “Brah”.
I know, it sends chills down your spine. But I am here to try to being to right this wrong. Unless you are a high school jock, or in some form of fraternity, you should NOT be allowed to use such terms or any variations. “Bro-dawg”, “Bro-dge”, “Broster”, all of those should be banned. There should be laws passed to punish those that think they are cooler for using such words.
There is nothing more disheartening then hearing a middle aged man call out to his middle aged friend, “Hey Brosiah.”
Please, join me in this fight. Please help me end such obnoxiousness. This is only one of the first steps in de-stupefying the world. All it takes is a fist. If you hear someone say any variations of the words listed above, please punch them and proclaim “You’re not cool!”
Thank you.
-Chad
Make the world a better place, punch brosephs in the face.
P.S. My word processor tries to auto-correct brosephs into brose pHs. I don’t know why, but I take it as a sign that even the computer is smart enough to know those people are wrong.
So yeah. A blog of some sorts? I construe I could construct a cacophony of concepts concocted by my cranial cavity here. Alliteration also, as I adore it. Essentially, I am the evil one. Every problem I encounter, my first thought is whether or not I can apply force to solve it.
Door stuck? Smash it. Sleeve caught on something? Rip it. You would not believe how short the lifespan of a pair of my pants is. This doesn’t mean I’m stupid; It’s just that I lack patience. If required, I can use tactics, strategy, guile, or any other Street Fighter character. Yes, that was a horrible Street Fighter pun. I don’t apologize. You can blame my father for that kind of thing.
That’s not to say I’m all bad. I hold rules in very high esteem. They keep us restrained. In check. They provide a structure and a set of guidelines for us to base our behavior around. I don’t refrain from committing crimes because my sense of morality tells me not to. I refrain from committing crimes because it is against the law, and there are definite consequences for such actions.
Around here, you’ll often see me posting about things that have pissed me off. Or not. To be honest, as this is the first blog-type-thing I’ve been involved in, I’m not sure how I will react. Perhaps I shall wax poetic about the virtues of having a fresh herb garden, with a weekly update on my latest aquisitions? Perhaps I shall bang out a manifesto on how ineffective an overly lenient criminal justice system is? Only time will tell.
— P
Immunologists attempt to achieve an understanding of how our body responds when under attack by antigens. The following is an explanation of the importance of T-cells in the immune response system. T-cells are part of our adaptive immunity to foreign pathogens. Two children of the Islayev family were found to have a flaw in their MHC. Tatiana and Alexander often suffered from chronic respiratory infections despite immunizations as infants. Analysis of their blood found low levels of CD8 T-cells, but normal levels of IgG, B-cells, and other lymphocytes which showed normal humoral immunity. Their parents and siblings were found to have normal levels of CD8 T-cells and immunity. The difference in CD8 T-cells expressed in Tatiana and Alexander from the rest of their family was directly related to their inability to respond to respiratory infections. CD8 T-cells recognize MHC class I molecules which present endogenous antigen. The antigen is cut into peptides by proteosome and transported into the endoplasmic reticulum (ER) by TAP where it binds to the peptide binding groove. The MHC molecule is assembled in the ER by chaperone proteins and leaves in a vesicle to present itself on the cell membrane. When a CD8 T-cell binds to it, an immune response is made. The cytotoxic T-cell recognizes the viral antigen presented and kills the infected cell. A second class of MHC molecules is MHC class II, which present exogenous antigen. MHC class II molecule is synthesized in the ER with an invariant chain on binding groove and travels by vesicle into the cytoplasm. The invariant chain cleaves and leaves a CLIP fragment on the groove. Antigen enters the cell and antigenic peptides bind to the groove displacing CLIP fragment. MHC molecule expresses the peptide at cell surface to CD4 T-cells. CD4 TH1 cells activate macrophages. CD4 TH2 cells activate B-cells to become plasma cells and release antibodies. In Tatiana’s and Alexander’s immune system, their MHC class II molecules were functioning properly but their MHC class I molecules weren’t. A mutation in TAP would prevent MHC class I molecules from fully maturing, therefore unable to present endogenous antigen to CD8 T-cells. Because Tatiana and Alexander inherited homozygous haplotypes from their parents, they have mutated TAP. The homozygous genes lower the number and type of peptide antigens presented because of the absence of MHC class I molecules on cell surface. With minimal MHC class I activity, they’re still able to have normal humoral immunity because their bodies produced normal levels of B-cells, T-cells and lymphocytes which recognize MHC class II molecules.